The current research in Wang Lab focuses on intestinal tissue engineering and intestinal regenerative medicine based on intestinal organoids and stem cells. As PI or co-Investigator on several university- and foundation-funded grants, Dr. Wang laid the groundwork for the proposed research by developing collagen I based gels for the culture of primary intestinal stem cells and use collagen I foams as cell carriers for the delivery of intestinal stem cells , and by demonstrating the feasibility to encapsulate DNA-functionalized gold nanoparticles into primary isolated intestinal stem cells to form an intestinal Trojan horse for gene regulation therapy of inflammatory bowel disease . Dr. Wang is aware the current major non-genetic cell engineering strategies for drug delivery and cell-based therapies [3, 4].
1) Peng H, Poovaiah N, Forrester M, Cochran E, Wang Q. Ex vivo culture of primary intestinal stem cells in collagen gels and foams. ACS Biomaterials Science & Engineering. 2015; 1(1):37-42.
2) Peng H, Wang C, Xu X, Yu C, Wang Q. An intestinal Trojan horse for gene delivery. Nanoscale. 2015; 7(10):4291-305. PMID: 25619169
3) Wang Q, Cheng H, Peng H, Zhou H, Li PY, Langer R. Non-genetic engineering of cells for drug delivery and cell-based therapy. Advanced Drug Delivery Reviews. 2015; 91(1):125-140. PMID: 25543006
4) Ikoba U, Peng H, Li H, Miller C, Yu C, Wang Q. Nanocarriers in therapy of infectious and inflammatory diseases. Nanoscale. 2015; 7(10):4291-305. PMID: 25680099