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Monthly Archives: July 2020

Congratulations to Dr. Sun!

Dr. Sun’s new manuscript, “TNFα Regulates Intestinal Organoids from Mice with Both Defined and Conventional Microbiota “, has been published on International Journal of Biological Macromolecules. Thanks to all collaborators on this long-term project. Dr. Rollins, Dr. Mansell, Dr. Jergens, Dr. Phillips, and Dr. Wannemuehler. Thanks to all members in the team. Congratulations!

AVN paper is published!

Yijun Qi’s new manuscript, “Transport of Artificial Virus-like Nanocarriers (AVN) through Intestinal Monolayer via Microfold Cells“, has been published on Nanoscale. It is collaboration with Tianjian Tong @ Prof. Chenxu Yu’s lab. In this study, inspired by mammalian orthoreovirus (MRV) transport into gut mucosal lymphoid tissue via Microfold cells (M cells), artificial virus-like nanocarriers (AVN), consisting of gold nanocages functionalized with the σ1 protein from mammalian reovirus (MRV), were tested as an effective oral vaccine delivery vehicle targeting M cells. AVN was shown to have a significantly higher transport compared to other experimental groups across mouse organoid monolayers containing M cells. These findings suggest that AVN has the potential to be an M cell-specific oral vaccine/drug delivery vehicle. Congratulations!