Dr. Wang gave a presentation about tissue engineering and regenerative medicine using organoids at Translational Medicine and Stem Cell Association (TMSCA) at UC Berkeley. The most recent research progress on biomaterials mediated organoids and stem cell reprogramming and organoids and cell-mediated drug delivery has been discussed. Stem cell research at UC Berkeley is organized and coordinated by the Berkeley Stem Cell Center, a cornerstone of the University’s Health Sciences Initiative.
Our drug delivery paper, “Folate Receptor-Targeted and
GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing
Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug
Delivery in Leukemia“, is among the Top 25 Most Cited Papers of Marine
Drugs, since 2018. Congratulations!
Dr. Zahra Davoudi and Dr. Yijun Qi have successfully defended the thesis for Doctor of Philosophy. Congratulations!
Dr. Wang will present “Manipulate Intestinal Organoids with Niobium Carbide Nanosheets” at World Biomaterials Congress (WBC) 2020, 11-15 December 2020. We are looking forward to sharing latest progress from Wang Lab with you. Cheers~
Dr. Sun’s new manuscript, “TNFα Regulates Intestinal Organoids from Mice with Both Defined and Conventional Microbiota “, has been published on International Journal of Biological Macromolecules. Thanks to all collaborators on this long-term project. Dr. Rollins, Dr. Mansell, Dr. Jergens, Dr. Phillips, and Dr. Wannemuehler. Thanks to all members in the team. Congratulations!
Yijun Qi’s new manuscript, “Transport of Artificial Virus-like Nanocarriers (AVN) through Intestinal Monolayer via Microfold Cells“, has been published on Nanoscale. It is collaboration with Tianjian Tong @ Prof. Chenxu Yu’s lab. In this study, inspired by mammalian orthoreovirus (MRV) transport into gut mucosal lymphoid tissue via Microfold cells (M cells), artificial virus-like nanocarriers (AVN), consisting of gold nanocages functionalized with the σ1 protein from mammalian reovirus (MRV), were tested as an effective oral vaccine delivery vehicle targeting M cells. AVN was shown to have a significantly higher transport compared to other experimental groups across mouse organoid monolayers containing M cells. These findings suggest that AVN has the potential to be an M cell-specific oral vaccine/drug delivery vehicle. Congratulations!
Brittney Reding’s new manuscript, “Manipulate Intestinal Organoids with Niobium Carbide Nanosheets“, has been published on Journal of Biomedical Materials Research Part A. In this study, Nb2C nanosheets were prepared by spark plasma sintering and HF etching. The results show overall potential benefits of placing low concentration Nb2C nanosheets in intestinal systems to protect and stimulate cell survivability when undergoing various treatments. Brittney is an undergradate research who has worked in Wang Lab since 2018. Congratulations!
Zahra’s new book chapter, “Skin Tissue Engineering with Nanostructured Materials“, has been published on Imaging Technologies and Transdermal Delivery in Skin Disorders. This timely book by Wiley‐VCH covers the latest understanding about today’s major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. Congratulations!
Dr. Wang has been invited to 2020 World Biomaterials Congress to present the research “Manipulate Intestinal Organoids with Niobium Carbide Nanosheets”. See you at Glasgow, Scotland in May!
In 2019, there are 6 manuscripts being published in peer-reviewed journals. Congratulations to all lab members and collaborators. We look forward a more productive 2020!