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AVN paper is published!

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Yijun Qi’s new manuscript, “Transport of Artificial Virus-like Nanocarriers (AVN) through Intestinal Monolayer via Microfold Cells“, has been published on Nanoscale. It is collaboration with Tianjian Tong @ Prof. Chenxu Yu’s lab. In this study, inspired by mammalian orthoreovirus (MRV) transport into gut mucosal lymphoid tissue via Microfold cells (M cells), artificial virus-like nanocarriers (AVN), consisting of gold nanocages functionalized with the σ1 protein from mammalian reovirus (MRV), were tested as an effective oral vaccine delivery vehicle targeting M cells. AVN was shown to have a significantly higher transport compared to other experimental groups across mouse organoid monolayers containing M cells. These findings suggest that AVN has the potential to be an M cell-specific oral vaccine/drug delivery vehicle. Congratulations!


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