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Gut Organoid Paper in Marine Drugs

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Dr. Zahra Davoudi’s paper, “Gut Organoid as a New Platform to Study Alginate and Chitosan Mediated PLGA Nanoparticles for Drug Delivery“, has been published on Marine Drugs. In this study, the impact of surface charge on the delivery of 5-ASA loaded PLGA nanoparticles into the lumen of organoids was investigated. It was concluded that the positively charged chitosan nanoparticles were more readily transported across the epithelium into the lumen than the negatively charged alginate nanoparticles. Thus, the organoid can be utilized as an appropriate model to mimic the functions of the intestinal epithelium and can be used as a model to evaluate the benefits of nanoparticle-based drug delivery. Congratulations to the team!


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